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Dapagliflozin also inhibits SGLT-2 in mice and regulates central autonomic activity by stimulating neurons in the central nervous system and controls cardiovascular functions

This is a very interesting concept that we can ponder in terms of regulating the health of the cells in the duodenum and the jejunum so that we can produce the GLP-1 appropriately again

The current best practice is risk-based shared decision-making rather than universal discontinuation

doi: 10.1038/nrendo.2010.187 47 UngerRHOrciL

Per Member Per Month (PMPM) Cost Pressures The financial challenges tied to GLP-1s are starkly illustrated by the rise in per member per month (PMPM) costs