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Clin Pharmacol Ther 90(5):674684

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Type 2 diabetes in adults: management (NG28) Initial medicines

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demonstrated that the GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant Apoe/Irs2+/ mice by promoting macrophage polarization towards an anti-inflammatory M2 phenotype, which was associated with enhanced plaque stability (i.e., thicker fibrous caps, fewer necrotic cores, and decreased inflammatory infiltrates)
