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The Phase 2 trial indicated that retatrutide is similar in terms of safety and side effects to tirzepatide and semaglutide, and the TRIUMPH-1 Phase 3 trial confirmed a manageable safety profile at all doses tested

Appetite suppression begins within the first few weeks for most patients

Wegovy has generated demand so explosive it has prompted manufacturing shortages, insurer pushback, and social media bans on celebrities and influencers promoting it

These are often the reason why patients stop taking the medication

Evidence Base in Older Populations Whilst landmark cardiovascular outcome trials included substantial numbers of older participants, dedicated studies focusing exclusively on elderly populations remain limited