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The SUSTAIN (Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes) trials were a series of global, randomized, controlled clinical trials that investigated the efficacy and safety of semaglutide in patients with type 2 diabetes

While phentermine is approved by the FDA for short-term use, many healthcare providers will prescribe it off-label for longer periods of time (or intermittently, with some time on and some time off)

It usually takes several months to see the full effect, as you start on a low dose, which is titrated up monthly

In an accompanying manuscript, we extended these findings to humans without obesity (Gonzalez Trotter et al

3 Strong glycemic control was observed in Type 2 Diabetes In the TRANSCEND-T2D-1 study, retatrutide reduced A1C by up to 2.0% from baseline while delivering 16.8% weight loss at 40 weeks