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Microdosing is also harder with oral GLP-1s

Meta-analysis in clinical trials revisited

If constipation worsens during dose escalation, Hamilton recommends talking to your prescribing physician

Poor sleep is associated with insulin resistance, increased hunger, and weight gain, which might reduce some benefits of GLP-1s [175]

About 10% of participants on the highest dose discontinued treatment due to their adverse events, compared to 5% of those on placebo
