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Summary: Retatrutide may appear ineffective due to factors including insufficient dose titration, individual pharmacological variability, poor injection technique, unaddressed medical conditions, or inadequate lifestyle changes

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First-line management includes drinking 1.52 litres of fluids daily, using paracetamol (maximum 4 g daily) or ibuprofen (maximum 1.2 g daily for over-the-counter use) as appropriate, and resting in a quiet environment

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But these properties are not sufficient reason to prescribe tirzepatide to someone who would not otherwise be a candidate