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Most common side effects Most common side effects of semaglutide and GLP-1s are: Nausea Vomiting Diarrhea Constipation Abdominal pain Headache Fatigue Indigestion Dizziness Bloating Gastroenteritis Most side effects are transient and mild to moderate in intensity

Sites with less fatty tissue might be more sensitive, leading to a more painful experience

Because Truveta Data provides timely, complete EHR data including prescriptions and medication dispense data that captures a large and diverse patient population, weve been able to compare the head-to-head effectiveness of these two important medications for weight loss in advance of smaller randomized clinical trials

This is largely based on individual experiences rather than clinical studies

American Cancer Society: Cancer Facts and Figures 2025