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Mental health and mood regulation The relationship between obesity, metabolic dysfunction, and mental health runs deeper than most people appreciate

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Although renin was discovered more than a century ago and the detection of angiotensin I, angiotensin II and aldosterone in the 50s allowed the definition of the classical RAAS pathway from 1961 (19), the research in this field continues and new evidence has recently emerged

Sensitivity tests Before PSM, the analysis of the crude populations showed consistent findings, indicating that GLP-1RA plus SGLT2i was associated with the primary composite outcome and individual outcomes compared to SGLT2i alone (Supplementary Table 4)