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The effect size was calculated here using the method of Cohens d for a t -test [49]
[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Seino Y

No evidence of increase in calcitonin concentrations or development of C-cell malignancy in response to liraglutide for up to 5 years in the LEADER Trial

The comparison in both cases was patients on an SGLT2 inhibitor, a different class of diabetes medication used as an active comparator

It appears to represent a recalibration of the brain's reward and satiety circuitry, reducing the hedonic drive to eat independently of hunger signals
