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In experimental models of obesity, agonism of GLP-1 receptors can improve cognitive deficits and depression with the activation of mTOR and the inhibition of autophagy [54]

The result is a double metabolic penalty: women burn fewer calories at rest while simultaneously feeling hungrier, a combination that standard diet and exercise often cannot overcome

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Meanwhile, the magnitude of weight loss with use of retatrutide was less pronounced in patients with type 2 diabetes at 36 weeks compared with obese subjects without diabetes at 48 weeks in the obesity trial (Table 1) [3]

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