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Limited head-to-head studies compare established glucagon-like peptide-1 receptor agonists (GLP-1 RAs), dipeptidyl peptidase-4 inhibitors (DPP-4is), and sodium-glucose co-transporter-2 inhibitors (SGLT-2is) to insulin in the management of uncontrolled type 2 diabetes mellitus (T2DM)

Semaglutide can support modest weight loss goals like 15 pounds, but outcomes depend on starting dose, treatment duration, lifestyle factors, and individual genetic predispositions in GLP-1 receptor pathways

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All these things can ultimately promote weight loss

However, they also affect how the digestive system works