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In Vivo Assessment of Drug Interactions Effects of Sitagliptin on Other Drugs In clinical studies, as described below, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, warfarin, or oral contraceptives, providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, and organic cationic transporter (OCT)

NICE recommends them when metformin and other therapies are insufficient, particularly for patients with high BMI, cardiovascular disease, or chronic kidney disease

doi: 10.1111/dom.14160 125 RakipovskiGRolinBNhrJKleweIFrederiksenKSAugustinRet al

The six inhibitors have been classified into three classes depending on their different binding modes in the DPP4 active center (10)