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Together with Daniel Drucker's paper it shows that neither Semaglutide nor Tirzepatide are good drugs to treat CNS diseases, as they do not cross the blood-brain barrier in meaningful quantities

This reflects its different chemical nature as a small molecule rather than a peptide

When to Be More Careful There are situations where estrogen changes may need closer attention: You already have low estrogen You experience rapid or significant weight loss You have a history of hormone-sensitive conditions In these cases, even beneficial weight loss can shift hormones in ways that affect how you feel

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There is a growing need for efficacious anti-obesity treatments that produce clinically meaningful, sustained weight loss and ultimately reduce the risk of developing associated metabolic comorbidities, such as diabetes, non-alcoholic steatohepatitis (NASH) and cardiovascular disease (CVD)