glp 1 and energy The effect of glucagon-like peptide-1 on expenditure substrate metabolism in humans GLP-1-based therapies for type 2
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I take this drug myself, so I've been sitting with this question from the other side of the counter

Additionally, GLP-1 analogs reduced energy expenditure, with only tirzepatide showing a significant decrease in the respiratory quotient (RQ) in MC4R KO mice

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The primary outcome was change in HbA1c from randomisation to the end of treatment, secondary outcomes included body weight change