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Incubating iGL cells with medium containing secreted Exe4 from scExe4-transfected cells significantly increased GSIS to a level comparable to that of iGL cells treated with commercial synthetic Exe4 peptide solution (Fig

Obes Surg 31:8492 [DOI] [PubMed] [Google Scholar] 25.Badurdeen D et al (2021) Efficacy of liraglutide to prevent weight regain after retrieval of an adjustable intra-gastric balloona case-matched study

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Results and discussion Peptide-oligourea hybrids design and functional assay Our peptideoligourea hybrids design started with GLP-1-NH 2 and the introduction of a glycine in position 2 of GLP-1 instead of alanine (GLP-1-G 2 , 1 ) as it is known to prevent DPP-4 degradation 31,32,33