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Of note, combination therapy faces significant barriers, including safety concerns in older or frail individuals, underutilisation in disadvantaged populations, while economic challenges may further hinder the accessibility of these therapies

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Additionally, GLP-1 analogs reduced energy expenditure, with only tirzepatide showing a significant decrease in the respiratory quotient (RQ) in MC4R KO mice
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It is equally a matter of strengthening public health systems and preventing complications that, in the medium and long term, impose far greater human and economic costs.Compulsory licensing: A rarely used legal toolInternational intellectual property law is not indifferent to public health concerns