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From a pharmacokinetic perspective, besides increased gastric emptying, obesity has been suggested to modulate CYP gene expression, and increased fat mass may result in an increased Vd of lipophilic drugs.210,211 The weight loss effects from GLP-1 RA treatment may reverse these changes and alter the pharmacokinetics of co-administered lipophilic drugs by decreasing the Vd (Figure 3)

References 1.Horowitz M, Maddox AF, Wishart JM, Harding PE, Chatterton BE, Shearman DJ

Due to the similar molecular mechanism between T2DM and AD, several drugs for the treatment of T2DM are increasingly being proposed for the treatment of AD (82)

Semaglutide focuses on regulating appetite and glucose via the GLP-1 pathway while Tirzepatide leverages the combined action of GIP and GLP-1 for a more potent, multisystem intervention

Using them together without medical oversight could lead to unpredictable and potentially harmful effects