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When combined with rapid glucose absorption from simple carbohydrates, this creates a scenario where insulin secretion overshoots, leading to reactive hypoglycaemia 13 hours postprandially

That pattern is often called Wegovy insomnia and can manifest as sleep disturbance, nocturnal awakenings, longer sleep latency, or restless nights as your circadian rhythm and REM cycles shift

Clinical data shows that patients combining semaglutide with 150 minutes of moderate-intensity activity per week achieve significantly better metabolic outcomes than those using medication without structured exercise

Glucagon-like peptide 1 (GLP-1) is an incretin 30 amino-acid peptide hormone produced in hindbrain neurons and in specialized enteroendocrine cells (L cells) in the distal small and large intestines that is released after food intake [23, 24]

Early Weeks Most people begin noticing appetite changes within the first few weeks