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For histological analysis, excised samples were fixed in 4% (w/v) neutral buffered formalin, embedded in paraffin and cut into 3 m slices for haematoxylin and eosin (H&E) staining or immunohistochemistry

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Mice were injected with BrdU in the last 3 d of the 14-d TAM chow period

Semaglutide works by mimicking a natural hormone (GLP-1) that regulates blood sugar and helps control appetite

GLP-1 activation can reduce the pathological process of amyloid- plaque aggregation/deposition and tau hyperphosphorylation enhanced by neuroinflammation, thus preventing age-related neurodegenerative changes, such as decline of learning and memory (Li et al., 2012)