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Beyond WL, these effects may be partly driven by its triple agonism, particularly glucagon receptor activation, which enhances lipid oxidation and reduces hepatic lipid synthesis [56]

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Although regulators reviewed data from more than 90 clinical trials involving over 100,000 patients and found no statistically significant increase in suicidal thoughts compared to placebo, critics argue the decision comes too soon

doi: 10.1038/s41598-019-51880-9

The therapeutic mechanism of GLP-1 RAs in this population primarily involves overcoming impaired sensitivity through pharmacological receptor stimulation [53]