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Iwai T, Suzuki M, Kobayashi K, Mori K, Mogi Y, Oka JI

LY3437943 has shown a powerful effect in reducing liver fat and liver injury markers in obese mice, which may be attributed to a combination of GCGR's direct impact on the liver or the indirect effects resulting from weight loss

Some studies have reported that depression caused by chronic stress disrupts the BDNFtropomyosin related kinase B (TrkB) receptor signaling pathway in the PFC and hippocampus, and ultimately contributes to impaired synaptic maturation, synaptic protein synthesis, and glutamate receptor cycling ( Therefore, because neurotransmitter imbalance contributes to depressive behaviors in patients with depression as described above, the appropriate modulation of neurotransmitters in the brain is key to treating depression ( Figure 2 )

Source: Polaris Market Research Analysis Regional Analysis Which Region Leads the Global GLP-1 Market