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Preferentially activates G protein-cAMP signaling over beta-arrestin recruitment, potentially reducing receptor desensitization

That does not mean every employer is pulling back, but it does mean the benefit is moving from novelty to budget line

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Since then, several human GLP-1 RAs, such as liraglutide, dulaglutide, semaglutide, and tirzepatide, have been developed, offering enhanced pharmacokinetic properties for more convenient administration [1]