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This side effect was more noticeable in patients who received the GLP-1RA treatment off-label, as a weight-loss medication

Specific modifications at the N-terminal positions one or two resulted in DPP4 resistance that led to enhanced insulin secretion in BRIN-BD11 cells and improvement of glucose tolerance in ob/ob mice

Dr Anjali Singh Scientific Writer & Content Editor All Posts Dr Anjali Singh Medicine and Diseases 24 September 2025 11:00 Reviewed by Dr Aarti Nehra (MBBS, MMST)

The program is designed for adults 18 and older who meet standard GLP-1 prescribing eligibility criteria - typically BMI 30 or higher, or BMI 27 or higher with at least one qualifying weight-related condition (such as hypertension, type 2 diabetes, dyslipidemia, or sleep apnea)

and Pyziak et al