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The temporal action profile thus alternates between resting periods (during which GLP-1 receptors are not activated) and intervals (lasting several hours) during which patients are exposed to effective circulating drug concentrations

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Furthermore, in neurons exposed to amyloid- oligomers, the insulin receptors are removed from the plasma membrane, suggesting that a state of neuronal insulin resistance occurs in AD [151,156]

As such, the effect of GLP-1RAs on DR should be viewed with caution

Argenxs FcRn inhibitor Vyvgart (Efgartigimod), approved in December 2021, entered the billion-dollar club by 2023