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Efficacy In the original phase 3 randomized trials for obesity, average weight reduction compared to placebo has ranged from 5.3% to 17.8% after 56 to 72 weeks (Table 1), with improvements in several obesity-related risks and complications

[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Sanyal AJ, Bedossa P, Fraessdorf M, et al

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Since Levenes test showed a statistically significant difference suggesting that variances were not homogeneous for some variables, we used the t-test level of significance when equal variances were not assumed to compensate for the lack of homogeneity

The mixture was stirred at 20C for 4 hours until completion of the reaction