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JAMA 309:22502261 Chang SH, Stoll CR, Song J, Varela JE, Eagon CJ, Colditz GA (2014) The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012

As we age, our hormones begin to play bigger and bigger roles in our lives

One of the mechanisms underlying the benefits of bariatric surgery is the increased secretion of glucagon-like peptide-1 (GLP-1), a gut-derived incretin hormone that enhances insulin release and inhibits glucagon secretion in a glucose-dependent manner (11)

These components work together to promote satiety, meaning youll feel fuller for longer, which naturally helps with reducing overall calorie intake

However, recent studies utilizing skeletal muscle-specific knockouts of both Akt1 and Akt2 demonstrated that deletion of both isoforms reduces both muscle size and muscle protein synthesis, indicating that only minimal amounts of Akt in muscle are needed to transmit downstream signaling and preserve muscle mass in vivo [19,20]