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In 2024 the Food and Drug Administration added cardiovascular risk as a reason to be prescribed the GLP-1 drug Wegovy, grounded in results from a major trial that showed fewer heart attacks, strokes, and cardiovascular deaths in adults with obesity or overweight and established heart disease

Received: 11 Jun 2025 | Revised: 29 Jul 2025 | Accepted: 31 Jul 2025 | Published: 27 Jan 2026 1

It is cleared renally rather than by DPP-4 digestion ( [46] )

GLP-1 , or glucagon-like peptide-1, is a hormone your body naturally produces after eating

Each compound contributes distinct mechanisms that, theoretically, produce better outcomes than any single agent alone