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A meta-regression analysis of GLP-1RA CVOT showed that the magnitude of HbA1c lowering, but not body weight (BW) loss, was associated with the prevention of renal outcomes [24]

Important issues to review include nausea, vomiting, constipation, diarrhea, reflux, hydration status, protein intake, muscle preservation, diabetes medications, gallbladder symptoms, kidney function, history of pancreatitis, thyroid and family history considerations, and long-term maintenance strategy

doi: 10.1111/dom.14255 Endocrine Society

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These observations support the hypothesis that GLP-1RAs may exert anti-inflammatory effects partly through the restoration of insulin responsiveness, rather than through weight reduction alone