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Several serious complications in clinical trials were linked to dehydration, including kidney issues

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JAMA 2024, 331, 654664

Luigi Barrea, Giuseppe Annunziata and Ludovica Verde equally contributed to this work as co-first authors

In addition, the number of reported adverse events has increased each year since the introduction of semaglutide, and the number of reported adverse reactions is generally higher in women than in men (Figure 2)
