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Protease-Independent Metabolic Effects of DPP-4 While some of the effects of DPP-4and, arguably, most, if not all of the pharmacological effects of DPP-4 inhibitors (38)on glucose homeostasis are mediated primarily by modulating the activity of the incretin hormones, it has also been proposed that DPP-4 may influence metabolic control via mechanisms which do not necessarily involve its catalytic activity, with several studies noting a positive correlation between DPP-4 and insulin resistance (79, 81, 88)

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By week three, theyve adjusted their eating pattern and the hunger is manageable

All images are dissected young adult gonads stained with sperm marker SP56 (red) and DAPI (cyan)

Contrary to this proposed hypothesis, our findings revealed that fetal blood insulin concentrations and -cell proliferation rates in fetuses from Sem-treated dams were comparable with those in the control fetuses (Fig