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Experimental models have shown that male and female animals differ in mitochondrial substrate utilization under stress conditions, though findings vary by context

A realistic way to think about GLP-1 medications: They improve the environment around lipedema (not the diseased tissue itself) GLP-1 belongs in the category of supportive tools similar to anti-inflammatory diet, metabolic care, and mobility support

While reducing training intensity is appropriate, stopping completely sends a strong signal to the body that muscle tissue is no longer needed

Zhang L, Krzentowski G, Albert A, Lefebvre PJ

In other words, the biggest decline is tied to new prescriptions of GLP-1 drugspeople starting on these treatments