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References Wharton S, Lau DCW, Vallis M, Sharma AM, Biertho L, Campbell-Scherer D, et al

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The FDA regulation requires any patient with a BMI over 30 or a BMI of 27 or more if they have a health-related obesity issue, including but not limited to high blood pressure, insulin resistance, sleep apnea or high cholesterol

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But the authors appropriately noted limitations: the retrospective design, small sample size, and the fact that most patients were already in remission when starting therapy

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A systematic review and meta-analysis of supervised-exercise training interventions in children and adolescents showed that both aerobic and resistance exercise, at vigorous or moderate-to-vigorous intensities, with a volume of 60 min/session and a frequency of 3 sessions/week, aiming to improve cardiorespiratory fitness and muscular strength had benefits on hepatic fat content reduction in youth [122]

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