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The evidence is not hypothetical

While FDA-approved GLP-1 injections like Wegovy and Zepbound have demonstrated 15-20% weight loss in clinical trials, GLP-1 patches lack any peer-reviewed evidence showing they deliver therapeutic blood levels or produce meaningful weight loss

Baseline and serial DEXA scans are non-negotiable to prevent replacing the morbidity of obesity with the frailty of iatrogenic sarcopenia

We then calculated time conditional propensity scores by using conditional logistic regression, conditional on the covariates listed below and stratifying on two variables: time interval and specific background drug