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Hayes asked whether the GLP-1 receptors develop a tolerance similar to what is seen with opioid receptors in the brain

Parthasarathy G, Kudva YC, Low PA, Camilleri M, Basu A, Bharucha AE

Thus, while there is much to be learned about the signaling that drives GLP-1-induced inhibition of glucagon secretion, there are multiple indirect and direct mechanisms at play

This requires a comprehensive assessment of the patients clinical characteristics, such as the duration of diabetes, presence of comorbidities, body mass index, and response to previous treatments