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Nausea, vomiting, diarrhea, and constipation were the most common gastrointestinal adverse effects
A new randomized clinical trial just published in JAMA Psychiatry tested semaglutide (a GLP-1 agonist) in people with schizophrenia, prediabetes, and obesity who were taking antipsychotics

Research has indicated that metformin treatment may lead to improvements in hormonal imbalances commonly associated with conditions such as PCOS by enhancing insulin sensitivity and indirectly decreasing biochemical hyperandrogenism

It can cause lumps, irritation, and slower absorption
These are not folk remedies or placebo effects but rather well-studied interventions that complement other strategies