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Inadequate protein intake, reduced physical activity, and dehydration may also contribute
D.Brown-FrandsenK.MarsoS
Metformin received FDA approval in 1994 for type 2 diabetes and with its beneficial effect on glycated hemoglobin (HbA1c), efficacy, and safety being wellestablished, 3 , 4 , 5 it became the recommended firstline choice for patients with type 2 diabetes in 2005
Diabetes 60 (4), 12461257
They also support insulin production and help control blood sugar, which can be especially helpful for people with type 2 diabetes
