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On average, patients who switched from semaglutide to orforglipron regained about 2 pounds of the weight they lost over the course of a year (almost 42 pounds total)

Using the 2.5 million estimate to be conservative, that works out to 550,000 people with OUD receiving indicated OUD treatment and 174,000 people with OUD being incidentally treated on GLP-1s

Shanes answers reinforce a common theme throughout the episode: progress is driven by consistency, realistic expectations, and intelligent adjustments based on readiness, recovery, and your actual goals

Some patients experience lingering fatigue for weeks after acute illness resolves

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