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Patients with preexisting ischemic optic neuropathy should be advised that there is a small but unproven risk of this agent causing NAION
Having actually run the studies on this and seen real patients, how much do you worry about the muscle loss component

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This review explores the roles of oxidative stress, autophagy, ferroptosis, epigenetic modifications, post-translational modifications, chronic low-grade inflammation, and gut microbiota in the pathogenesis of PCOS
