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Radel JA, Pender DN, Shah SA (2019) Dipeptidyl peptidase-4 inhibitors and inflammatory bowel disease risk: a meta-analysis

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It is interesting to note that the positive effect of tirzepatide on body weight is associated with a significant improvement in quality of life and physical performance [50] and is independent of sex [51], baseline body mass index (BMI) [52] and potential side effects, predominantly gastrointestinal [53]

Some users find that they need slightly higher fiber doses than semaglutide users to achieve the same constipation relief, particularly at higher tirzepatide doses

Symptoms typically improve within 4-8 weeks as the body adjusts to therapy, though this timeframe varies by individual and dose