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Injection-site irritation often develops within hours or days of administration

Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system

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Additionally, the delayed gastric emptying induced by GLP-1 agonists could theoretically worsen symptoms in patients with stricturing Crohn's disease or those at risk for bowel obstruction

25 Conclusions Understanding the enteroinsular axis has been the basis of seminal advancements in the therapeutic approach to diabetes management, with translation of research discoveries into effective pharmacologic therapies