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Adeniron E et al

MSTN and activins both negatively regulate muscle growth, [13] prompting the development of inhibition strategies that also target activin A

Modification of Epicardial Adipose Tissue Epicardial adipose tissue (EAT), which is a store of visceral fat located between the myocardium and pericardium, has been implicated in the pathogenesis of ASCVD and has been shown to confer a pro-inflammatory milieu for the neighbouring coronary arteries [149]

1 The LEADER trial (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome ResultsA Long-Term Evaluation), a large double-blind, placebo-controlled trial, recently demonstrated that liraglutide added to standard therapy for a relatively short period of time (3.5-5 years) had a significant reduction in cardiovas-cular events and mortality compared to placebo in high-risk patients (hazard ratio [HR], 0.87

Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy