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The Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) is a study comparing sitagliptin with placebo in diabetic patients with a previous history of cardiovascular disease

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Athletes using GLP-1s will need to closely watch their diet and training to make sure they maintain muscle (perhaps while dealing with the vomiting, nausea, and diarrhea often associated with GLP-1s)

GLP-1 receptor agonists are peptides for a reason: the receptor is tuned for peptide hormones, and the downstream satiety circuitry responds to sustained signaling

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