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These are absolute contraindications based on animal study findings

Preclinical studies also indicate that tanycytes, specialized glial cells within the CNS, may facilitate the transportation of peripheral GLP-1RAs, such as semaglutide, into the CNS, bypassing the blood-brain barrier to access appetite-regulating hypothalamic regions such as the arcuate nucleus (60, 61)

However, some research has examined transitioning from high-dose tirzepatide to retatrutide as a sequential approach

Alopecia Associated With The Use Of Semaglutide And Tirzepatide: A Disproportionality Analysis Using The FDA Adverse Event Continue reading Increased reporting odds of hair loss for: Semaglutide (199 cases) Tirzepatide (179 cases) No increased reporting odds of hair loss for: Liraglutide (20 cases) Dulaglutide (65 cases) Exenatide (6 cases) Lixisenatide (0 cases) There are a substantial number of reported cases of hair loss with the use of semaglutide and tirzepatide GLP-1 medications

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