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Whether orforglipron's effects on bone health are net positive (through receptor-mediated bone protection) or net negative (through sustained caloric deficit and weight loss reducing mechanical loading on bones) will need to be determined through long-term surveillance studies

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Protective effects of glucagon-like peptide-1 on cardiac remodeling by inhibiting oxidative stress through mammalian target of rapamycin complex 1/p70 ribosomal protein S6 kinase pathway in diabetes mellitus

Endocrinology 149 , 56795687, (2008)

Just two capsules daily