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Tirzepatide adds a second mechanism: it also mimics glucose-dependent insulinotropic polypeptide (GIP), a closely related incretin hormone

IBS-C: The Risk of Increased Constipation Conversely, for those with IBS-C (constipation-predominant), the introduction of a medication that slows motility requires careful consideration

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A centenary of gastrointestinal endocrinology

If the price is high relative to the benefit, NICE can restrict access to specific patient groups (for example, only those with very high BMI or particular comorbidities), or reject NHS use altogether