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They are administered by subcutaneous injection (weekly, daily, or twice-daily) or as an oral tablet (semaglutide), with pre-filled pens for self-administration

Intravenous infusion of GLP-1 for 48 h in healthy human subjects increased muscle sympathetic nerve activity but had no effect on BP, norepinephrine plasma concentration, or the sympathetic/parasympathetic balance as estimated by the HR variability, suggesting that the increase in sympathetic drive is at least partially compensated by an increase in the parasympathetic activity [53]

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Therefore, they use small doses to help their body adjust, maintain weight, or ease into therapy in a way that seems more manageable

This latest research suggests it can also be a valuable preventative treatment for people at high risk of heart conditions.