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S1), which phenocopy a predominant subset of women suffering PCOS, who display overweight or obesity and may be exposed to unhealthy Western diets 39,40

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This could potentially be explained by the greater levels of semaglutide exposure as a result of the lower mean baseline body weight in PIONEER 12 than in PIONEER 3 (79.5 kg vs 91.2 kg) [18, 25]

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Systematic rotation across approved sites (at least 2-3 cm apart within a site, then switching to a different anatomical location) minimizes this risk