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For example, argininosuccinate synthase 1 (ASS1), and ornithine transcarbamylase (OTC) expression status have been used to identify patients who are likely to benefit from arginine-targeted therapies, including arginine deiminase and PEG-arginase therapies, which are showing great promise in improving the sensitivity of a subset of lung and liver tumors to standard-of-care therapies (1820)

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It has been speculated that the observed difference in gender may be due to the difference in smoking intensity.3 One of the limitations of our study is the lack of detail on exposure intensity, i.e

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