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Determination of the Nicotine Metabolites Cotinine and Trans-3-Hydroxycotinine in Biologic fluids of Smokers and Non-Smokers using Liquid Chromatography - Tandem Mass Spectrometry: Biomarkers for Tobacco Smoke Exposure and for Phenotyping Cytochrome P450 2A6 Activity

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This has serious implications for the population as whole

[176] The study suggested "that television increased the share of smokers in the population by 515 percentage points, generating roughly 11 million additional smokers between 1946 and 1970." [176] In the United States, a 2019 analysis by the Centers for Disease Control and Prevention of top-grossing films released during 20102018 found that, although the number of films with any tobacco imagery remained stable, the total number of tobacco incidents in those films increased by 57%, including a 120% increase in PG-13-rated movies