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The price increase follows Altrias typical quarterly cadence, so it doesn't come as much of a surprise, although the increase is a bit sharper than prior increases, likely given the ongoing pressures on cigarette volumes, Herzog said

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The main pathological changes are found in the small airways with epithelial remodeling including goblet cell metaplasia, basal cell hyperplasia, leading to thickening of small airway walls and obliteration [4]

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